Not that I subscribe to a pessimistic viewpoint. I just don't believe doctors have the right to give false hope, or to take a patients hope away. Between my journey towards a degree in Molecular, Cellular Biology and my work as a registered nurse in acute care and hospice, I've seen plenty of both. In the two years and a week since diagnosis I've learned that patients living with type 1 diabetes for 30+ years suffered that refrain from their own Day One, and again and again as the years, then decades, passed by.
My take on the idea of a cure encompasses supporting research, but not getting too excited; keeping our focus on healthy management and learning to live with D without letting D take over. I don't lack faith in a cure someday, but doubt that one in my child's lifetime proves unlikely. Until yesterday...
I read a post by Diabetes Dad over on his blog. It create some level of curiosity. At 10:08pm last night, while attempting to keep myself awake for the next BG check (unplanned new pump site - at bedtime, a not so great idea), the promised DRI link went live. Of course I jumped on it.
Wow. I read. I cried. Keep in mind, I'm the quintessential don't talk to me about close loop pump / cgm systems, I'll never trust an implanted machine to do all the thinking / analyzing / work kinda gal. In fact, I pretty much expect that what we're doing now works, for the most part, and I don't expect that to change in her lifetime - at least not before Miss N reaches senior citizen status. Last night? That changed.
Words like impressive, possible, not that far off swim through my mind. I admit to some level of surprise at the lack of enthusiasm bordering on anger I've encountered within the DOC by this latest we're close to the cure revelation. More so, I'm surprised at my own sense of hope in light of the news release. I truly believe that a cure is now possible, and not necessarily that far off.
The research scientists at the DRI have proven their sheer genius - and an uncanny but much needed ability to collaborate and work multiple avenues towards a true biological cure - and the BioHub really is just that. A bio-engineered, (perhaps some component of nanotechnology) mini organ with vascular support and the appropriate helper cells to ensure viability.
See, that's the problem with islet cell transplantation right now. Not only is it cost prohibitive at $250K / transplant, and a life time of anti-rejection therapy - something we can't even begin to contemplate for our youth. The islet cells in transplants don't last - the autoimmune process that attacked our child's pancreas in the first place attacks them, lack of oxygen, inflammation caused by seeding them into the liver - all these things place a finite time on the bio-availability and functionality of islet cells following transplant. Available only to those between 18 and 65 who struggle with the hardest to control cases of type 1, islet cell transplants involve trading one set of problems for another. Kim White does an amazing job of sharing the realities in her own blog.
The folks over at DRI address all of that in the various approaches to the biohub - including the possibility of local versus systemic anti-rejection therapy, encapsulation that will protect the islet cells from autoimmune destruction, placement in an area of the body that would provide a rich vascular supply (oxygen and nutrients.) This isn't mere theory, or testing in animals, this is years of work by multiple scientists and research centers coming together and converging in what will likely be a true cure. Imagine implanting a device no larger than a quarter, and no longer needing insulin to manage blood sugars!!
|picture courtesy of DRI|